T. Colin Campbell, whose name appears second on
Diet, Life-style and Mortality in China: A Study of the Characteristics of 65 Chinese Counties is certainly the most well known figure associated with this study. He is the one who's been interviewed concerning it and has been promoting it. I think that we can agree that in doing so he has greatly distorted the findings of that large and comprehensive epidemiolgical paper. I think that it is fair to criticize Campbell and his interpretations of the study, particularly that work of propaganda/fiction that he published as "The China Study" but I have come across no one who has impugned the data from or execution of the original study (other than the normal limitations of epidemiological research, of course, and that some of the questions were poorly worded). The fact that he has been misusing and perverting the data to his own end does not mean that the original data is flawed.
I think that this is analogous to Wrangham. We can accept the data of the python study without having to accept any of Wrangham's far-fetched conclusions. It would be a career-killer for Stephen Secor, who has studied and published more about the digestion of pythons than anyone else, to publish research that could be so easily falsifiable by anyone else who is willing to do the experiment. I do not claim that Wrangham set the conditions and that some junior scientist did the work. As reported by Science and Health journalist Rachael Gorman,
http://www.rachaelgorman.com/article_full.php?article_stamp=1202161241, Wrangham sought out Secor because he already had experience studying the evolutionary design of the digestive system. Yes, the research found what Wrangham wanted it to find and he uses it to prop up his theories, but I don't think that that indicates the data to be erroneous any more than I think that the data actually supports his theory. As I've said before, I find it very hard to believe that the snake data in isolation tells us anything meaningful about the human digestive tract. I also don't think that this study tells us anything about the quality of the nutrition that the snake is absorbing. It just tells us that the snake can absorb cooked food more quickly and with less energy than it can raw food.
This is a mere technicality. Here's another study which proves my point:-
http://jn.nutrition.org/cgi/reprint/7/4/367.pdf
The above is a comparison between raw meat and 3 types of cooking at various temperatures, 1 of which involved cooking at 66-75 degrees Celsius for a period. All 3 cooking-methods showed a decrease in nutritive value and a clear drop in digestibility of meats after heating:-
"By the criterion of growth promoted among young rats(table 3), quite parallele differences are deduced. The raw meat is superior to all the cooked products, since each gram of raw meat protein eaten produced 0.78+/- 0.7 gm greater gain(i rats) than did that auto-claved 1 hour, 0.17 +/- 0.6 more than the boiled and 0.14 +/- 0.06 more than that autoclaved 7 minutes.
I do not think that this study proves your point any more than the Oste one does. The Morgan Kern study is a comparison of raw meat along with 3 samples cooked in different ways. One sample was boiled until an internal temperature of 84C was reached. The second was autoclaved at 15 pounds of pressure for 7 minutes, giving a temperature of 84C. The last was autoclaved at 15lbs of pressure for 1 hour. The authors did not measure the temperature of this sample, but admit that it probably exceeded 85C. 84C is equivilent to 183F and is far beyond well done. At no time did the authors of this study examine lightly cooked meat.
The reference to a sample cooked from 66-77C is not from this study but is mentioned as the author discusses all previous studies done in this area of research. This number came from the work of Jarawussa in '29. Jarawussa's study found absolutely zero difference in biological value when comparing the raw substance with the cooked. I say substance instead of meat because Jarawussa used a mixture of "100 gm. of meat, treated in one of the ways given above, with 40gm. of potatoes, 20 gm. of cabbage and 10 gm. of carrots." Even if the Jarawussa study had only looked at meat and had come to a conclusion that the raw meat showed a difference in biological value it still wouldn't tell us anything about cooking meats to Rare (46-51C). 66C (151F) is considered medium rare by the USDA, but any chef in a kitchen will tell you that their numbers are wacky and that 66C is more Medium to Medium-Well.
The other aspect is that since enzymes start getting destroyed at c.40 degrees Celsius, digetibility of meat is reduced. Yes, I know, that pro-cooked-advocates deny the uses of enzymes in raw food, but given the above facts re digestibility of protein being reduced at only slightly higher temperatures, it's clear that they are quite wrong.
If by "the above facts re protein digestibility being reduced" you are referring to the Oste, Morgan and Jarawussa studies and not something else that I've overlooked then I hope that I have demonstrated that they do not tell us anything about what happens between, say, 40C and 60C. The question about whether enzyme rich foods actually benefit us or if the enzymes are all broken down into basic amino acids in the stomach seems to be still up in the air. It is still possible that the enzymes are deactivated at 40C but that there is no change in protein digestibility until 58C, to pick a random number.
The issue of the AGE's is more complicated and one where I will have to spend much more time reading through the references that you have provided before I feel that I'll be able to comment intelligently.
On phytonutrients and plants it seems that if too many cause harm and too few give no benefit then cooking which, depending on the method chosen and how it is executed, reduces but generally does not eliminate these compounds and which, according to Oste, makes the plants more digestible might be the preferred way to prepare and consume them.