Thanks for sharing your experience, aLptHW4k4y. You're negative experience is one reason I don't prescribe to others, wouldn't want anyone doing anything I do just because I have success with it, and encourage people to investigate things themselves before trying them, and if there are any risks, to discuss it with a healthcare practitioner. I would also caution people to be particularly careful with zinc and the pyridoxine HCL form of B6, for which there is far more evidence of side effect risk than P5P, as there is for other most other vitamins.
Instead of prescribing, I just share my experience. Before considering trying pyroluria-related supplements I first read up extensively on it, learned about how to check and monitor my zinc and B6 levels, checked my health status before and continued to monitor during therapy, and I try to track significant stuff in a health journal. One thing I read is that
B6 supplementation "should be balanced by vitamin B12 and biotin" http://perfecthealthdiet.com/category/supplements, which are often included in B complex supplements, which fits with what DaBoss said. I saw Mg mentioned in this regard once too, which I was already using in epsom salt baths as well as supplementation. I also read that one should avoid supplements that contain folic acid, which many B complex supplements do, and instead look for folate. Unfortunately, my current supplements contain folic acid, so I'll look for that in the future.
P5P is supposed to be energizing, via helping the mitochondria produce energy, and I found that taking a big dose close to bed did seem to keep me up that night, so I try not to take any after 8pm. My latest dose of the day is taken with supper.
On the P5P and skin front I currently take much more P5P than you and luckily I haven't had any new or worsened negative skin issues since doing so. Coincidentally I was just noticing yesterday that the skin around the cuticles of my fingers is further improved to probably the best it has been in decades. It used to peel quite a bit in that area and the remnant peeling has cleared up. I do sometimes take other B vitamins and other supplements, though I don't get any additional skin issues when I don't.
Something else I do that could be helping my skin but is not raw is consume some low-heated bone broths (I keep meaning to try raw broths too). I tried a bone meal supplement and kosher gelatin powder, but seem to get the best results from bone broths, though it's difficult to say with multiple factors at play.
I agree with trying to eat as much of the whole animal as one can manage and I also eat lots of fat and avoid excess protein. I do notice that my skin does better when I eat more fat and less of the easily-digestible carbs.
Various health issues, such as enzyme deficiencies and gut dysbiosis, are indeed known to inhibit absorption of b vitamins and other nutrients, so that unfortunately not everyone is able to get all the nutrients they need just from whole foods and not everyone heals overnight.
I'm also concerned that taking supplements every day might in the long run depress my body's own ability to generate the nutrients, so I don't take them every day, aside from P5P (and some days I take much less of that), and I'm trying other foods and therapies that are supposed to help the body produce its own nutrients (blogger Todd Becker writes about this). For example, prebiotic fermentable fibers reportedly promote the good bacteria that are said to heal the gut and aid with breaking down and absorbing nutrients. My hope is to some day not need any supplements.
