This is something that I have wondered about, too. I do think that
some changes are possible, however slight. I don't believe that any large changes have had a chance to occur, though.
If there is enough time for physical changes on the outside. There is enough time for internal changes too. Correct? Enough time for humans to get diverse on the outside, but not on the inside? That doesn't make sense.
I understand the temptation of equating these two types of changes: digestive and appearance. One change involves elements of the metabolic system: stomach, intestines, etc. The other involves skin. We are talking about organs, but we can't necessarily say that if one organ can change over short periods of time, then other (all) organs can do the same. This might be the case, and it might not, but making an external change and an internal change interchangeable (pun intended) because they sound the same is a logical fallacy. IMO, much more research needs to be done in this arena.
If people are susceptible to different genetic tolerances of food, then that's something we would all be better off knowing about.
There are, however, some decent arguments regarding short-term digestive changes. Like Kristelle pointed out, some people can digest lactose. She also alluded to chronic disease being the result of these kinds of dietary changes. One argument along these lines is that early in the Neolithic period, the massive dietary shift away from carnivorism and toward grain eating might have resulted in a large number of deaths of people who absolutely could not handle the new foods. As long as they died before reaching the age of reproduction (ie. problematic birth, childhood issues, etc.) then they would not have had a chance to pass this massive food intolerance on to future generations. Those that did survive to reach reproductive age would have been our ancestors, and thus, most people tend to have some measurable tolerance to "unnatural" foods, at least for awhile. I guess you could call this Artificial Selection. Note, however, that chronic diseases that can kill you at the age of thirty (due to sub-par nutrition) would not have been bred out, and would have been passed down as most people tend to reproduce when they're young (and apparently) healthy. Tolerance
might have been passed down but complete adaptation would probably take far longer to achieve.
And as far as skin goes: remember that its the organ that takes the most beating on a consistent basis. Unlike the digestive system which could depend on the same foods for millions of years long ago, the skin was always and is always exposed to vastly different environments. It seems logical that if anything were going to change in the short term, it would be the skin, eyes, hair, etc.