I wondered if supplements that are supposed to boost glutathione would also trigger more of this phenomenon of reducing the brown/melanin in the iris (and thus revealing more green, blue or gray color).
One such supplement is Guardian Ultrathione, which Art De Vany believes has reduced the gray in his hair:
Art De Vany in his 70's
"The picture shows how little gray hair I have. I have less gray hair now than I had at the age of 40. I have attributed that to my intake of Ultrathione, the source of glutathione in Guardian."
http://artdevanyonline.com/1/post/2012/12/the-free-radical-theory-of-graying1.htmlAnd an animal study jibes with this:
"hair graying ... is attributable to a loss of melanin produced by oxidative stress, thus raising the possibility that hair graying constitutes a signal of resistance to oxidative stress in wild boars. Our results suggest that the degree of melanization is linked to GSH levels in wild boars and that their antioxidant damage shows senescence effects."
http://www.ncbi.nlm.nih.gov/pubmed/?term=graying+hair+glutathioneAnd hair graying is known to be reversible in humans:
http://www.natureworldnews.com/articles/1745/20130503/bye-gray-hair-researchers-find-way-reverse.htmOn the other hand, it looks like his wife has a fair amount of gray hair, though she looks great overall and she also has T1DM.
But I Googled and I did find some people reporting lightened eye color from glutathione supplements:
"Yes, glutathione can lighten eye color. I experienced this myself. After 7 months of taking glutathione supplements, people have been asking if I were wearing contact lenses, which I wasn't.
I don't know about KB though as it's not "real" glutathione."
http://www.pinoyexchange.com/forums/showthread.php?t=432335&p=51784017&viewfull=1#post51784017Iodine too:
http://www.longecity.org/forum/topic/44985-eye-color-change-with-iodine-supplementation/And Iodine is known to increase glutathione levels:
http://www.ncbi.nlm.nih.gov/pubmed/7685786Though oddly I found no reports of NAC supplements (NAC is supposed to boost glutathione production) doing this.
There is a scientific explanation for how cysteine and glutathione may lighten iris color:
"In uveal melanocytes, the quality and quantity of melanin vary with race and iris color. In the uveal pigments, pheomelanin is often present in addition to eumelanin (21-23). Pheomelanin is a lighter colored, yellowish pigment that is formed when cysteine or glutathione is present during the oxidation stage of dopa (24). 1,4- benzothiazynylalanine, derived from cysteinyldopas, is proposed to be a key intermediate in the biosynthesis of pheomelanin (24). The quantity of uveal melanin in eyes with dark-colored irides is greater than that in light-colored eyes (21,23,25). Uveal melanocytes contain both eumelanin and pheomelanin. In cells from eyes with dark-colored irides (brown and dark brown in color), the amount of eumelanin and the ratio of eumelanin/pheomelanin is significantly greater than that from eyes with light-colored irides (hazel, green, yellow-brown and blue in color) (23). The quantity of pheomelanin in uveal melanocytes from eyes with light-colored irides is slightly greater than that from dark-colored irides, although the difference is not statistically significant (23)."
http://www.youreyesolutions.com/blog/item/role-of-ocular-melanin-in-ophthalmic-physiology-and-pathologyThere are even reports of glutathione supplements and injections lightening skin, and it has become all the rage in Asia:
Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled study.
http://www.ncbi.nlm.nih.gov/pubmed/20524875"Oral glutathione administration results in a lightening of skin color in a small number of subjects."
Investigating the Effectiveness of Glutathione as a Melanin Inhibitor
http://www.usc.edu/CSSF/History/2010/Projects/S1804.pdf"majority of the subjects tested experienced a significant lightening of their skin tone especially for those who took the pill and use the lotion" (although one subject developed spots on her face)
> "Animal tests showed that a high cysteine level (the main component of glutathione) lowers melanin production."
> "Another study on glutathione as a skin whitener will be released next month, November 2011, conducted by dermatologists from the Philippine Dermatological Society (PDS).
The study was conducted among 40 respondents who were asked to drink 500mg of glutathione capsules in 10 weeks. Only 14 users finished drinking the pills in the controlled group. Of these, 11 manifested minimal whitening of the skin."
http://www.abs-cbnnews.com/-depth/10/10/11/white-skin-comes-price"experts have raised four theories to explain the possible whitening effect of the tripeptide, based on animal and in vivo studies using melanoma cell lines. Glutathione may directly deactivate tyrosinase, the main enzyme in melanin synthesis; sop up free radicals and peroxides that promote tyrosinase activation and melanin formation; or enhance the depigmenting abilities of melanocytotoxic agents. Another proposed mechanism is the triggering of a pathway that shifts the production in eumelanin (black to brown pigment) to pheomelanin (yellow to red-brown pigment)."
http://www.medobserver.com/specialtyarticle.php?ArticleID=7http://www.vitaminmaster.com/faq.html"Someone said my skin lightened by 20 shades (but of course she was exaggerating)."
http://www.pinoyexchange.com/forums/showthread.php?t=432335&p=52037465&viewfull=1#post52037465http://answers.yahoo.com/question/index?qid=20080302153957AA4x1k5