My understanding is that chili and cayenne peppers are both nightshades. Nightshades contain natural insecticides at relatively high levels (as compared to luscious fruits and greens) that recent research has shown may be a problem for people with autoimmune disorders (and tendencies in that direction). I used to poo-poo the talk about nightshades contributing to inflammation, arthritis, etc., but eventually I tried eliminating them and found that my health improved significantly as a result. So I don't poo-poo the dangers of nightshades anymore.
I'll repost some stuff I posted before on this, because I think that most people are unaware of the dangers with nightshades (as I had been largely unaware):
Tomatoes contain natural toxins that act as natural insecticides and anti-fungal agents: tomato lectin and alpha tomatine. Tomato lectin and alpha tomatine can work together to increase gut permeability and contribute to “leaky gut syndrome,” which itself can contribute to IBS, arthritis and a host of modern syndromes and diseases.
Many plant foods (generally speaking, the nonfruit plant foods) contain natural insecticides they use to defend themselves against insects and other predators. The human digestive system has evolved enzymes that break down and thus detoxify some of these plant toxins, but it appears it has not had enough time to develop this adaptation to certain plant foods, such as tomatoes and other nightshades, and it may be that it cannot completely detoxify even the plant foods to which we are most adapted without additional help (after all, even mountain gorillas must regularly detoxify by supplementing with clays or charcoal to avoid excess accumulation of plant toxins, despite many millions of years of adaptation to eating plant foods).
The Centre for Drug Delivery Research in the UK and the Faculté des Sciences Pharmaceutiques in France state that "Tomato lectin (TL) is a bioadhesive glycoprotein that has been shown to bind selectively to the small intestine epithelium."
[html=
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T7W-3WMJSNY-3&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=fd27edca692b7072d14f7f8a2ee6bf28]Studies on the uptake of tomato lectin nanoparticles in everted gut sacs[/html]. Tomato lectin interacts with gastric parietal cells in patients with autoimmune gastritis (see
http://jcs.biologists.org/cgi/content/abstract/95/4/563).
Here is an excerpt of a presentation by Dr. Cordain on MS and diet that discusses tomato lection and alpha tomatine:
How to Treat Multiple Sclerosis with Diet (multiple videos; covers the role of tomatoes in MS)
http://www.youtube.com/watch?v=xhkmDHLCUEs From the description: "Of Tomatoes, Vaccines and Autoimmune Disease - Tomatoes are almost universally considered to be healthy foods, though there are anecdotal reports that
avoiding consumption of nightshade plants, including tomatoes,
may improve symptoms in patients with rheumatoid arthritis and other autoimmune diseases.
In this cutting-edge report you'll learn about a component, tomato lectin, which has the capacity to interact with the immune system in a way that may promote autoimmune disease. You'll also learn about another component of tomato, alpha tomatine, which can act as an adjuvant and boost the immune response to tomato lectin, and also increase gut permeability."
Here is Ashton Embry, the MS diet expert, discussing Dr. Cordain’s presentation:
The Role of Lectins from Grains and Legumes in the MS Disease Process
Ashton Embry
http://www.msrc.co.uk/index.cfm?fuseaction=show&pageid=2344 "I want to summarize a number of important points that Dr Cordain made in his presentation. Some of them were new to me and they are most important for understanding why it is essential to avoid eating gluten grains and legumes as well as a few other types of foods including tomatoes. His work has also put the concept of the role of a leaky gut in MS in a new context and this also has ramifications for understanding how potentially problematic food and bacterial-derived protein fragments can cross the intestinal barrier and engage the immune system. Dr Cordain’s presentation is quite technical but to me it is imperative to understand how various proteins derived from foods can be part of the MS disease process on a molecular level. This provides a solid, science-based rationale for WHY it is critical to avoid foods such as legumes and grains if one wants to keep the MS disease process well controlled."
It was quite a shocker for me to learn that some of the foods that we were taught by scientific consensus and media hype to consider “superfoods” are not necessarily so super, and I’m sure it will be quite a shock to many other people as well and there will be enormous resistance to accepting this, unsurprisingly. We are on the cusp of a revolution. Such changes to the reigning order tend to be tumultuous.