Correction to my last post: I should have written "(anaerobic) cellular fermentation" rather than "anaerobic cellular respiration".
Well, there is certainly no real-world evidence for longer lifespans on ZC as the Inuit were not known for being particularly long-lived. Plus, there's the Bear's example of throat-cancer which shows that ZC doesn't protect against cancer at all, even after decades.
Yeah, I agree that the evidence indicates that Inuit lifespans weren't as long as current Americans' and I neither recommend nor follow Bear's diet or lifestyle and I disagree with some of his views. I also don't think it's necessary or necessarily optimal to precisely emulate Inuit diets. I wasn't referring to any of that, I was referring to the purported benefits of aerobic cellular respiration per basic biology ("Lactic acid fermentation,"
http://en.wikipedia.org/wiki/Lactic_acid_fermentation. See also "Cellular respiration,"
http://www.all-science-fair-projects.com/science_fair_projects_encyclopedia/Cellular_respiration, and "Biology Notes: Chapter 8 – Respiration,"
www.helpfulnotes.com/files/biology/bch8.pdf) and the Warburg hypothesis (
http://en.wikipedia.org/wiki/Warburg_hypothesis), and findings re: mitochondrial biogenesis and slowdown in cellular aging ("Mitochondria and Aging,"
www.actionbioscience.org/genomic/wallace.html) and nothing more. Here are some links for more info on the connection between ketogenic diets and mitochondrial biogenesis:
> Energy metabolism as part of the anticonvulsant mechanism of the ketogenic diet,
http://www.ncbi.nlm.nih.gov/pubmed/19049599?>
http://www.ncbi.nlm.nih.gov/pubmed/18582445?> Induction of ketosis may improve mitochondrial function and decrease steady-state amyloid-beta precursor protein (APP) levels in the aged dog,
http://www.ncbi.nlm.nih.gov/pubmed/19168117?> Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet,
http://www.ncbi.nlm.nih.gov/pubmed/16807920?> Polyunsaturated fatty acids of marine origin [EPA and DHA] upregulate mitochondrial biogenesis and induce Beta-oxidation in white fat.
http://www.cababstractsplus.org/abstracts/Abstract.aspx?AcNo=20053209661Other factors have been reported to promote mitochondrial biogenesis as well, and I certainly didn't mean to imply that fat-heavy diets are the only factor:
> Resveratrol induces mitochondrial biogenesis in endothelial cells,
http://ajpheart.physiology.org/cgi/content/abstract/00368.2009v1> NO Says Yes to Mitochondria,
www.sciencemag.org/cgi/content/short/299/5608/838> Calorie restriction increases muscle mitochondrial biogenesis in healthy humans,
http://www.vetscite.org/publish/items/003569/index.htmlOne doesn't have to be ZC to use cellular respiration. You're own diet (you last reported 5 - 25% carbs, as I recall) is probably low enough in carbs, high enough in fats, and possibly high enough in certain other substances like resveratrol to experience substantial aerobic cellular respiration and we may learn of other plant compounds that promote cellular respiration, which may turn out to partly explain how some peoples, like the Kitavans, do so well on relatively high-carb diets. Some VLC experts have dismissed the Kitavan and Tarahumara examples, but I'm still interested in what we can learn from them. They eat lots of cooked carbs, however, so you may not be interested in those examples. Do you know of any examples of peoples who eat relatively high carb diets that are as raw as those of the Inuit, Chukchi and Nenets? That would be an interesting comparison.
Whether any of this results in any lengthening of lifespan or not I don't know, as there have been no studies investigating that, AFAIK. I was thinking more in terms of quality of life than lifespan. I know that many people appear to place lifespan as a top priority, and it is worth consideration, but my focus tends to be more on quality of life.
Do you have any info that shows aerobic cellular respiration or mitochondrial biogenesis to have bad effects? I'm interested to learn of any downsides to these processes.