Gloria was actually the first U2 tune I think I heard played on the radio during the days of my youth in Boston and it was quite a hit and very different from the other stuff being played (not many songs included Latin lyrics, for example). I think it might still be my favorite U2 song, but it's already been posted, so here's some other music from when I was still fairly young in Boston:
Dropkick murphys Skinhead on the MBTA Boston Irish punk rock band (that got their start and were still fairly small potatoes when I was living in the greater Boston area) covering an old campaign song of a Boston politician that became popular in folk circles. Dropkick Murphys became rather popular and some of their songs are played regularly at Fenway Park. I was surprised the first time I heard Skinhead of the MTA being played at Fenway, years ago. It brings back memories of Boston when I hear their music played on radio and TV broadcasts of Bosox games.
Here they are playing another of their cover songs that gets played on the Fenway Park sound system, Dirty Water, during a 2007 World Series championship celebration:
"Dirty Water" Dropkick Murphys, Rolling Rally 07 Warning: Dropkick Murphys are best listened to whilst seriously trashed, such as in the pubs of Fenway after a Red Sox victory (or defeat, any excuse'll do

).
This hit by two Boston groups dominated MTV and rock radio stations for quite a span while I was living in Boston:
RUN-DMC - Walk This WayAnd here's another memory from further back, a song that was pretty popular in my high school days in Vermont:
hells bells