... but also there have been studies showing how AGEs directly and negatively affect human cells in vitro
OK, could you share with me what you think is the best one of those studies and a couple more studies that you think are the best of all on AGEs or heat-related toxins and I'll take a look at them. I've checked out some of your studies before, but maybe they'll be ones I haven't reviewed yet. I don't need convincing to eat raw anyway, but if they're good they might help me in responding to questions or criticisms from non-rawists.
it is perfectly understandable that when someone makes lame, unscientific comments in favour of the Noble-Savage theory or some other pro-cooked-oriented or pro-raw vegan topic(or tries to rewrite history by previously pretending that cannibalism was not as prevalent as claimed in palaeo times), that one should naturally step in and criticise such a move.
There you go again with your straw men. I'll probably regret asking it, but you keep bringing this vague "Noble Savage" complaint up, often directed at no one in particular and seemingly at the same time at anyone who disagrees with you, so could you please explain in more detail what you think the "Noble-Savage theory" is (preferably in a separate thread, to avoid sidetracking this one), who was the originator of it and who were the major historical promoters/supporters and who are the leading ones today? And could you please provide a passage of text or two that is an example of Noble Savage theory promotion by one of today's prominent theorists? Do you think that anything written in this thread promotes it? If so, then please provide a quote demonstrating it. If you cannot do these things then it may be much ado about nothing.
[I deleted out my comments on Tyler's "beyond absolute doubt" remarks which were based on a misreading by me--my apologies to Tyler for that one]
one only has to accumulate far more scientific evidence in favour of one's hypothesis than evidence favouring other viewpoints.
Isn't it wise to also consider credible contrary evidence and where the evidence is weak or absent, not just tally up studies that support one's bias? Science also involves questioning one's own assumptions and putting them to the test in various ways, not turning them into absolute dogmas.
Here are interesting suggestions from blogger Alex Tabarrok on how to better evaluate studies:
What can be done about these problems? (Some cribbed straight from Ioannidis and some my own suggestions.)
1) In evaluating any study try to take into account the amount of background noise. That is, remember that the more hypotheses which are tested and the less selection which goes into choosing hypotheses the more likely it is that you are looking at noise.
2) Bigger samples are better. (But note that even big samples won't help to solve the problems of observational studies which is a whole other problem).
3) Small effects are to be distrusted.
4) Multiple sources and types of evidence are desirable.
5) Evaluate literatures not individual papers.
6) Trust empirical papers which test other people's theories more than empirical papers which test the author's theory.
7) As an editor or referee, don't reject papers that fail to reject the null." (http://www.marginalrevolution.com/marginalrevolution/2005/09/why_most_publis.html)
The greater the difference between them, the more likely it is that the one side with the larger studies is right, and the other smaller one wrong.
An overwhelming accumulation of evidence is indeed significant, but it's not a guarantee of "absolute" certainty. The consensus of the Western scientific community has been wrong about things in the past. Darwin and Huxley had to argue for years to get biological evolution accepted as a scientific model, for example, overturning the previous consensus. If the scientific consensus was never wrong then there would be no scientific revolutions and thus no Darwininian evolution. The scientific consensus is also wrong about some things today, such as supporting the USDA food pyramid and similar nonsense instead of a raw Paleo diet or any type of Paleo or raw diet for that matter.
The lame argument that all other studies are wrong, just because one says so, makes no sense.
Yet another one of your tiresome straw men. Neither Yuli nor I nor John Ioannidis have written that all other studies are wrong just because we say so. I'm not even arguing that the studies are wrong, only that you can't assume that they are all absolutely correct just because they support the consensus, nor can you assume that the conensus is absolutely correct.
Even if one believes in conspiracy-theories such as that almost all scientific studies are biased or are flawed...
To be precise, the article reports that Ioannidis "charges that as much as 90 percent of the published medical information that doctors rely on is flawed." It's not a conspiracy theory, it's a paper that has been broadly accepted and confirmed within the medical community:
Ioannidis initially thought the community might come out fighting. Instead, it seemed relieved, as if it had been guiltily waiting for someone to blow the whistle, and eager to hear more. David Gorski, a surgeon and researcher at Detroit’s Barbara Ann Karmanos Cancer Institute, noted in his prominent medical blog that when he presented Ioannidis’s paper on highly cited research at a professional meeting, “not a single one of my surgical colleagues was the least bit surprised or disturbed by its findings.” Ioannidis offers a theory for the relatively calm reception. “I think that people didn’t feel I was only trying to provoke them, because I showed that it was a community problem, instead of pointing fingers at individual examples of bad research,” he says. In a sense, he gave scientists an opportunity to cluck about the wrongness without having to acknowledge that they themselves succumb to it—it was something everyone else did.
To say that Ioannidis’s work has been embraced would be an understatement. His PLoS Medicine paper is the most downloaded in the journal’s history, and it’s not even Ioannidis’s most-cited work.... (http://www.theatlantic.com/magazine/archive/2010/11/lies-damned-lies-and-medical-science/8269/)
So if you were consistent in applying your own frequently-cited guide of consensus, you would conclude that there must be something to Ioannidis' report, because the consensus, or at least a major part of the medical community, appears to accept it.
Now, one could pretend that absolutely all the studies favouring one side were a-ok, while absolutely all studies favouring the opposite side were totally flawed and corrupt
Methinks the fox smells himself.
this is physically impossible as human bias, flawed studies etc. appear all the time, favouring all kinds of different viewpoints, affecting all sides.
We agree here and that is part of what Ioannidis reported. So we should remember to keep in mind that studies can be flawed, especially in certain fields like medicine, and that interpretations of study data can add another layer of error (Ancel Keys' misrepresentations of his data on saturated fat and T. Colin Campbell's bogus interpretations and misrepresentations of The China Study data are famous examples of this), and that we shouldn't treat study interpretations as absolute truths.
What cannot be denied, nowadays, is that cooking heavily causes harm to foods. That is now mainstream thought.
It is mainstream thought and everyone seems to agree at least that cooking everything to a cinder is a bad idea, for example. On the other hand, the current consensus appears to be that there are some subtleties to it, as you indicate here:
Granted, there are still some delaying tactics with many scientists claiming, despite evidence of toxins in such foods, that boiled/lightly-cooked foods are somehow OK because they are "less worse" than well-cooked foods, but that is to be expected since humans have been eating cooked foods for so many millenia.
If we accepted the consensus, as you advocate, then we'd have to say that low-and-slow is the way to go, rather than all raw. There isn't a single major scientific, medical or nutritional organization that advocates an all-raw diet. So can you see how the consensus can sometimes be wrong?
Thanks Michael. Excellent post, and not just because you agreed with me.
We don’t have to prove that raw food is healthy, safe or whatever: it has been the normal nutrition of all living things on Earth ever since the appearance of life on Earth 3.7 or 3.8 billions years ago. Moreover, biochemistry show without the slightest shadow of a doubt that heat damages or destroys complex organic macromolecules, which in turn can cause various troubles in living organisms.
It belongs to the cooked food proponents to show that heating and cooking is harmless and that we are perfectly adapted to it (not only to be able to reproduce and perpetuate the specie). So far, this has not been done.
I agree, Iguana. Just because the current consensus advocates certain forms of cooking doesn't guarantee that the consensus is correct. They are starting from the wrong default reference point. They start with modern diets and ask "Why should I eat raw?" or "Why should I eliminate this modern food from my diet?" instead of starting from nature's default and asking "Why should I cook?" or "Why should I add this modern food into my diet?" This is one reason why I'm not particularly concerned personally if studies don't show any harm from certain forms of cooking. Eating raw is the default position of nature, I'm already eating raw and benefiting from it in various ways beyond health benefits, so I would need good reasons to eat cooked, not reasons to eat raw.
I'd also be interested in what you think is the best biochemistry study on this.
Nobody can live on 100% cooked and sterilized food.
Right. I think it's safe to say that even our harshest critics would agree that cooking everything to a cinder is a bad idea.
Iguana makes a good point. Strictly speaking, the burden of proof is on pro-cooked-advocates to show that cooking is harmless.
I agree.
I would love to see a study on middle-aged people doing 100 percent cooked diets for a decade or more.
No one is advocating that, so there wouldn't be much point.