But I do like eat as much fat that appeals to you, eat moderate amounts of protein, and nibble on prebiotics throughout the day,, a lot better.
This appears to actually fit with Jeff Leach's approach. Agreement is not required, but it's interesting and welcome when it occurs.
Quite honestly I don't even think carb content matter as much as the type of carb
Genetics is probably the biggest factor here - How strong is the digestive system for that person? How good is he tolerated with various pathogens and gut bacteria? How fast can he eliminate those pathogens and LPS within the system..?
Yes, you made some good points, such as these, if I may paraphrase them to summarize:
1) There are "good" carbs as well as "bad" carbs (more precisely, there are good carby foods as well as bad ones), just as you and Gary Taubes suggested that there are "good" fats as well as "bad" fats (and this is partly dependent on the overall balances).
2) How badly carbs impact you depends in part on how robust/antifragile you are to shocks from stressors like too much bad carbs at one blow (due to how strong the digestive, microbial, mitochondrial and other systems are).
3) (A corrolary to #2) It's not just important how many toxins you consume, but also how well your sytem works to detoxify them. So we should look at the whole systemic picture, not just toxin avoidance.
While genetics is a factor, the 90% of the genes in your body that are in microbes may be more important than the 10% that are in your cells. Plus, changeable epigenetics and horizontal gene transfer may be more important than fixed genetics.
Again, sort of how people have been using it anyways. Some people use ZC to get rid of cancer (went on mainstream with the Ketogenic diet of bacon, butter, eggs etc), some people use mod-high carb to deal with temperature issues.
Ketogenic diets are not a slam-dunk treatment for all cancers. It came out that some cancer cells may also feed on ketones, and thus ketogenic diets are not recommended for certain forms of cancer. You won't often see this disclosed by LC advocates, though Dr. Eugene Fine, cancer researcher at Albert Einstein College of Medicine and LC diet advocate who uses a ketogenic diet as a therapy, did candidly acknowledge the issue:
"Some cancers may indeed depend on ketone bodies. Our hypothesis, in fact states that some cancers may be adapted to the effects of carb restriction, including ketosis (i.e. may continue to grow), and others may be vulnerable to ketosis."
http://livinlavidalowcarb.com/blog/do-ketones-fuel-cancer-the-low-carb-experts-respond/10124Recent research has been investigating this issue:
Ketone body utilization by breast and prostate tumors
Simon Authier1, Sebastien Tremblay1, Veronique Dumulon1, Celena Dubuc1, Rene Ouellet1, Roger Lecomte1, Stephen Cunnane2 and Francois Benard1
J Nucl Med. 2007; 48 (Supplement 2):340P
http://tinyurl.com/p5js8xhKetones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.
Bonuccelli G1, Tsirigos A, Whitaker-Menezes D, Pavlides S, Pestell RG, Chiavarina B, Frank PG, Flomenberg N, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP.
Cell Cycle. 2010 Sep 1;9(17):3506-14. Epub 2010 Sep 21.
http://www.ncbi.nlm.nih.gov/pubmed/20818174New studies explain how cancer cells 'eat us alive'
Sep 01, 2010
http://www.physorg.com/news202553643.html"Four key studies now propose a new theory about how cancer cells grow and survive, allowing researchers to design better diagnostics and therapies to target high-risk cancer patients. These studies were conducted by a large team of researchers at Thomas Jefferson University’s Kimmel Cancer Center."
A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer.
Pértega-Gomes N, Vizcaíno JR, Attig J, Jurmeister S, Lopes C, Baltazar F1.
BMC Cancer. 2014 May 21;14:352. doi: 10.1186/1471-2407-14-352.
http://www.ncbi.nlm.nih.gov/pubmed/24886074The reverse warburg effect in osteosarcoma.
Oncotarget. 2014 Sep 30;5(18):7982-3.
Sotgia F1, Martinez-Outschoorn UE, Lisanti MP1.
http://www.ncbi.nlm.nih.gov/pubmed/25327555A reverse Warburg metabolism in oral squamous cell carcinoma is not dependent upon myofibroblasts.
Jensen DH1, Therkildsen MH, Dabelsteen E.
J Oral Pathol Med. 2014 Nov 25. doi: 10.1111/jop.12297.
http://www.ncbi.nlm.nih.gov/pubmed/25420473I agree, and, I also say for those who want to know what carbs or sugar is doing to their insulin or blood sugar levels, and what effect that may have long term on health, there is plenty of information to discover and ponder, if not test for one self. But one has to be able to allow for change. I for one, for many years bought up the notion if it's fruit, or if it's raw, the sugar or carbs won't hurt you.
And I would add one of Iguana's favorite heuristic's--Claude Bernard's "the terrain is everything." It's a bit of an exaggeration, but how harmful or beneficial the fruit or sugar is depends in great measure on how well equipped the terrain/milieu/environment/habitat (pH of the intestines, GI microbiome, mitochondria, cell fitness, genetics, epigenetics, and so on) is to handle it. The hypothesis is that if you can find a way to improve that terrain, then fewer carby foods will be harmful for you and those that are still harmful will be less so.
