Here are some sources on amenorrhea:
Paleo and Amenorrhea: How Extremity Can Make even the Best Diet Fail,
http://www.paleoforwomen.com/how-extremity-can-make-even-the-best-diet-failThe Female(?) Athlete Triad - Part II/III: LH, GH, IGF1, Insulin, Ghrelin, Leptin & Co Form a Self-Perpetuating Vicious Cycle,
http://suppversity.blogspot.com/2012/09/the-female-athlete-triad-part-iiiii-lh.htmlI've noticed many reports of amenorrhea by raw vegans and fruitarians, with some of them even claiming that it's a sign of good health!
Ray Peat wrote this about avocados: "Not all fruits, of course, are perfectly safe—avocados, for example, contain so much unsaturated fat that they can be carcinogenic and hepatotoxic." (
http://raypeat.com/articles/articles/vegetables.shtml) Yet one of the sources he cited (
http://www.ncbi.nlm.nih.gov/pubmed/1776821) found a significant marker of increased liver fibrosis only in unrefined avocado oil, not refined avocado oil (and raw whole avocados were not even tested). Refining removes allergenic proteins from oils (
http://www.ncbi.nlm.nih.gov/pubmed/10722892).
Chitinases and chitinase-like lectin proteins, which are found in avocados and other plant foods, have been linked to the processes in fibrosis, cancer and inflammatory bowel disease (
http://en.wikipedia.org/wiki/CHI3L1, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181078/). This suggests that the problem could be with the chitinase proteins in avocadoes, rather than the PUFA or MUFA content (and it could also be that "the dose makes the poison"). The abstract for the other source he cited (
http://www.ncbi.nlm.nih.gov/pubmed/9891232) does not indicate what sort of "avocado" product was tested.
Chitinases are also found in bananas, chestnuts, kiwis, avocados, papaya, tomatoes (
http://en.wikipedia.org/wiki/Chitinase) and other plant foods. They are defense-related plant proteins that break down the chitin in the cell walls of fungi and insects. They might theoretically do the same in sensitive humans at sufficient doses. They are also known to trigger allergic reactions. Like other lectins, they might potentially trigger autoimmune reactions.
Ray Peat made the chitinase - cancer connection here -
http://raypeat.com/articles/articles/milk.shtml - but didn't address it in his Vegetables article.
I don't seem to fare well on avocados myself, but I don't yet see enough evidence to make a connection between the PUFA or MUFA in avocados and liver fibrosis and I suspect that any lectin issue would be dependent on dosage and differences between individuals.